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The Other Novo Doesn’t Need Ozempic

At an industrial hub about an hour outside Copenhagen, engineered yeast cells are fermented to produce semaglutide, the key ingredient in Ozempic and Wegovy, the highly sought-after GLP-1 drugs made by pharmaceutical giant Novo Nordisk. Denmark has a long history as an important contributor to biomedical innovation, including the diabetes treatments for which Novo Nordisk is known. The company, one of the largest employers there, produces half the world’s insulin and was among the first to commercialize its use a hundred years ago.

But Novo Nordisk isn’t the only company in the neighborhood that uses the alchemy of fermentation science to turn microbes into high-demand products. It isn’t even the only Novo.

Just around the corner from the cauldrons of Ozempic is another facility, where three-story fermentation tanks are similarly filled with bacteria and fungi multiplying by the millions in a nutrient-rich broth. The enzymes that get secreted are eventually used by dozens of industries to make everything from food and laundry detergents to biofuel and medicines. The Novo that produces and sells these enzymes is Novonesis.

The similarity in the names isn’t a coincidence. That’s because, until 2000, the two Novos were one company. More than two decades after their corporate breakup, their headquarters, some labs, and production plants remain near one another (and both businesses continue to be controlled by a holding company for the Novo Nordisk Foundation).

“Novo” is Latin for new, and that’s what industrial enzymes were in the 1940s, when the original company introduced its first enzymatic products—one used to clean leather hides before they are tanned, and another for textile desizing, in which amylase breaks down starch agents to prepare fabrics for dyeing. The company was also a pioneer in synthetic biology, launching its first enzyme derived from genetically engineered microorganisms in 1987; lipase is still used today in detergents to help remove stains deposited by a greasy burger or pizza, and some of Novonesis’s biggest customers are Procter & Gamble and Unilever.

Enzymes are proteins that act as catalysts to speed up chemical reactions. For example, they are naturally found in the stomach and help break down food into tiny particles that can be converted into energy. In industrial settings, they are used as a substitute for harsh chemicals, which tend to require higher temperatures and pressure to carry out the necessary reactions. The use of enzymes also prevents unwanted reactions, as each type of enzyme binds only to specific molecules, thus leaving behind less waste than traditional chemicals that could give off hazardous byproducts. And industrial enzymes are a good business: While they comprise a small portion of a manufacturer’s overall cost of goods sold, the switching costs can be high, which gives enzyme suppliers pricing power over their customers. This is especially true for Novonesis, given that it is the dominant player in the oligopolistic niche market.

Another source of strength for Novonesis is its research-and-development strategy. The company has historically spent much more on R&D as a percentage of sales than competitors such as DuPont, DSM, and BASF, and that investment has produced a number of important products and thousands of patents over time. In 2024 alone, Novonesis introduced 45 new products, and 30% of its revenue comes from products launched in the past five years.

Novonesis recently acquired its Danish competitor, Chr. Hansen, which supplies bacteria cultures and probiotics used in products such as yogurts. (The US$12.3 billion deal closed last year.) There are product-level advantages to putting the companies together. For example, adding protein to yogurt changes the texture and taste, but Novonesis can now combine products to better address those issues. Management has said it sees similar synergistic opportunities around food preservation for baked goods.

Revenue growth had been bumpy for Novonesis over the past decade, but recently it has gained positive momentum. Pro-forma sales climbed 5% in 2024 (8% when excluding the negative effects of currencies and acquisitions), and the company projects organic sales growth of 5% to 8% this year. The long-term outlook also looks attractive because there remains a significant opportunity for enzymes to displace chemical additives in industrial production processes. The clearest example is detergents, as producers emphasize products that are more water efficient, enable washing machines to run at lower temperatures, and use fewer harsh chemicals. An expanding middle class in emerging markets could also increase the demand for better household-cleaning products.

It’s also at lower US tariff risk than some other European companies, given that Novonesis has R&D and production facilities in the US, and most of its demand there is fulfilled by local production.

It may not be one of the companies shaking up the splashy market for weight-loss solutions, but Novonesis happens to possess a lot of the traits that investors admire about its better-known sibling: cutting-edge research that allows it to succeed in high-growth markets. For Novonesis, that growth strategy is beginning to bear fruit.

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Wise’s Money-Transfer Business Has Inadvertently Become a ‘Narrow Bank’

With regulators in both the US and UK looking at revamping the rules around banking, now is a good time to reconsider what it even means to be a bank. Today, virtually every bank in the world is a “fractional reserve bank.” In broad strokes, fractional reserve banks take depositors’ money and promise to give it back whenever the depositor asks for it. The bank then sends that money out to their other customers either in the form of loans or securities, earning money on the difference in interest rates between what it gets from borrowers and what it pays depositors.

This is helpful to society because it allows that capital to be recycled and put to productive use by consumers and businesses. But lending borrowed money comes with several different kinds of risk. Most notably, there is credit risk, where borrowers fail to pay back loans to the bank. Duration risk comes when long-term interest rates on the loans and securities are low but short-term rates are rising; the banks therefore can sell assets only at a loss (i.e., the assets are “underwater”) and cannot afford to pay the new, higher rate of interest that depositors demand. And liquidity risk hits when a bank’s assets are still worth more than its liabilities, but the depositors want their money right now and the loans won’t be paid back for some time. In other words, the money is tied up. As George Bailey explained in the famous bank-run scene in It’s a Wonderful Life, “The money’s not here. Well your money’s in Joe’s house, that’s right next to yours, and in the Kennedy house and Mrs. Mayklin’s house and a hundred others.”

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Why Own International Stocks?

For more than a decade, equity returns in international markets have trailed those of the US. There are various possible explanations, but a central one is that the US, after first staging a faster recovery from the global financial crisis, has tended to produce stronger earnings growth in the years since. Meanwhile, from an international perspective, everything from a strong dollar to geopolitical conflict to volatility in emerging markets to China’s economic slowdown have weighed on relative returns. It also doesn’t help that the arrival of ChatGPT, and the enthusiasm and competition it has inspired for generative artificial intelligence technology, has lately encouraged an almost singular focus on a handful of US tech stocks—out of nearly 2700 index constituents, a mere 0.2% of the companies in the MSCI ACWI Index.

Some investors look at the difference between international and US returns and, expecting that current conditions will persist, wonder what place non-US equities have in a portfolio today. But while it’s easy to fall into that line of thinking, history suggests it is likely wrong. The relative performance of US and non-US stocks has historically been a cyclical phenomenon, and as the chart below shows, their indexes have regularly swapped between leader and laggard over the past 50 years.

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Ozempic and the Substitution Trade

The diabetes drug Ozempic has made headlines recently as the secret behind several slimmed-down stars of the Bravo network’s “Real Housewives” franchise. Tabloid fodder doesn’t usually matter to investors, but the story of Ozempic is one worth reading.

The twist is that Ozempic, a trade name for semaglutide, is a diabetes drug, not an obesity drug. Semaglutide is however effective in inducing weight loss; its creator Novo Nordisk markets a separate version called Wegovy specifically for obesity. Wegovy became so popular there were shortages of it, so doctors began prescribing Ozempic “off label” for a condition other than its intended use. That popularity fueled Novo Nordisk shares and this month it pushed past LVMH as Europe’s most valuable company.